Author

D. Bruder

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 8 Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 2 Assay:flow cytometry· 2 Organism:human· 2

Frequent Co-Authors

J. D. Boehme· 3 shared K. Schultz· 3 shared L. Cicin-Sain· 3 shared A. Jeron· 2 shared J. Boehme· 2 shared L. Melcher· 2 shared S. Stegemann-Koniszewski· 2 shared A. Diefenbach· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersImmunology

J. D. Boehme

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota

I. Roewekamp, L. Maschirow, A. Rabes, F. Fiocca Vernengo, G. A. Heinz, M.-F. Mashreghi, S. Caesar, M. Milek, A. Fagundes, S.-M. Wienhold, G. Nouailles, L. Yao, D. Bruder, J. Boehme, M. Puzianowska-Kuznicka, , B. Opitz

This study shows IL-33 reduces IL-22 production in innate lymphoid cells, increasing resistance to Streptococcus pneumoniae infection, and links genetic variation in IL-33 signaling to human pneumonia.

bioRxiv · Jul 19, 2023Immunology

Epigenetic changes and serotype-specific interferon-responses of lung epithelial cells in late post-influenza pneumococcal pneumonia

J. D. Boehme, A. Jeron, K. Schultz, L. Melcher, K. Schott, E. Gelmez, A. Kroeger, S. Stegemann-Koniszewski, D. Bruder

This study investigates how IAV infection alters the transcriptional and epigenetic responses of lung epithelial cells to pneumococcal serotypes, revealing serotype-specific interferon responses and epigenetic changes.

bioRxiv · Jun 28, 2023 · PreprintImmunology

TMPRSS2 is essential for SARS-CoV-2 Beta and Omicron infection

K. Metzdorf, H. Jacobsen, M. C. Greweling-Pils, M. Hoffmann, T. Lueddecke, F. Miller, L. Melcher, A. M. Kempf, I. Nehlmeier, D. Bruder, M. Widera, S. Ciesek, S. Poehlmann, L. Cicin-Sain

The paper shows TMPRSS2 is essential for SARS-CoV-2 Beta and Omicron infection in mice, highlighting its role as an antiviral target.

bioRxiv · Dec 9, 2022Immunology

Tracking influenza a virus infection in the lung from hematological data with machine learning

S. Jhutty, J. Boehme, A. Jeron, J. Volckmar, K. Schultz, J. Schreiber, K. Schughart, K. Zhou, J. Steinheimer, H. Stocker, S. Stegemann-Koniszewski, D. Bruder, E. A. Hernandez Vargas

This study uses machine learning to predict lung viral load and immune markers from hematological data in a murine influenza infection model.

bioRxiv · Feb 23, 2022 · PreprintMicrobiology

Influenza A virus (H1N1) infection induces microglia activation and temporal dysbalance in glutamatergic synaptic transmission.

H. P. Düsedau, J. Steffen, C. A. Figueiredo, J. D. Boehme, K. Schultz, C. Erck, M. Korte, H. Faber-Zuschratter, K.-H. Smalla, D. Dieterich, A. Kröger, D. Bruder, I. R. Dunay

This study shows that H1N1 influenza infection causes microglia activation and temporary dysbalance in glutamatergic synaptic transmission in mice.

bioRxiv · Aug 30, 2021Immunology

Antiviral activity of influenza A virus defective interfering particles against SARS-CoV-2 replication in vitro through stimulation of innate immunity

U. Rand, S. Y. Kupke, H. Shkarlet, M. D. Hein, T. Hirsch, P. Marichal-Gallardo, L. Cicin-Sain, U. Reichl, D. Bruder

This study shows that influenza A virus defective interfering particles inhibit SARS-CoV-2 replication in vitro by enhancing innate immunity through JAK/STAT signaling.

bioRxiv · Feb 19, 2021Microbiology

Influenza A virus-induced thymus atrophy differentially affects dynamics of conventional and regulatory T cell development

Y. Elfaki, P. A. Robert, C. Binz, C. S. Falk, D. Bruder, I. Prinz, S. Flöss, M. Meyer-Hermann, J. Hühn

This study investigates how influenza A virus-induced thymus atrophy affects Treg cell development and shows a relative increase in tTreg cells with reduced TCR diversity.

bioRxiv · Sep 9, 2020Immunology

Topological data analysis to uncover the shape of immune responses during co-infection

K. Sasaki, D. Bruder, E. A. Hernandez-Vargas

The paper uses topological data analysis to study immune response dynamics during influenza-pneumococcal co-infection in mice, revealing three phases and two transition points in the immune response.

bioRxiv · Aug 5, 2019Immunology

Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge

X. Zheng, J. D. Oduro, J. D. Boehme, L. Borkner, T. Ebensen, U. Heise, M. Gereke, M. Pils, A. Krmpotic, C. Guzman, D. Bruder, L. Cicin-Sain

This paper shows that intranasal immunization with an MCMV-based vaccine vector induces lung-resident memory CD8+ T cells that protect against influenza challenge.

bioRxiv · Dec 12, 2018Immunology