Epigenetic Gatekeeping of Wnt-Responsive Enhancers Restricts Intestinal Stem Cell Transformation
Alireza Lorzadeh, Sweta Sharma, George Ye, Sabrina Rabaya, Yun Jee Kang, Ramesh A. Shivdasani, Unmesh Jadhav
This study identifies H3K27me3 as an epigenetic barrier that restricts intestinal stem cell transformation by maintaining enhancer repression and preventing fetal gene reactivation in colorectal cancer.
bioRxiv · Jun 8, 2026 · PreprintCancer Biology