Therapeutic CD8+T cell tissue retention and immunomodulation during ART interruption fails to prevent SIV rebound
María Betina Pampena, Sadia Samer, Elise G. Viox, Kevin Nguyen, Claire Deléage, Leticia Kuri-Cervantes, James Regan, Vincent H. Wu, Steffen S. Docken, Jeffrey T. Safrit, Katharine J. Bar, Brandon F. Keele, Miles P. Davenport, Mirko Paiardini, Michael R. Betts
This study shows that retaining CD8+ T cells in lymphoid tissues during ART interruption does not prevent SIV rebound, even with immunomodulators.
Proceedings of the National Academy of Sciences · Aug 14, 2025Peer-reviewedImmunology