Mirko Paiardini

This study shows fractalkine-conjugated mRNA-LNP can target and modify CD8+ T cells in vivo, enabling transient expression of proteins like IL-2 and CD62L.

This study shows that IL-6 restricts pre-thymic T cell lineage commitment in SIV-infected rhesus macaques, contributing to loss of viral control.

This study shows that retaining CD8+ T cells in lymphoid tissues during ART interruption does not prevent SIV rebound, even with immunomodulators.

The paper shows that tazemetostat reduces HIV reservoirs and improves CD8+ T-cell function by increasing MHC-I expression and promoting anti-HIV immune responses.

This study shows that the S2-targeting antibody CC40.8 reduces SARS-CoV-2 viral loads and lower airway inflammation in rhesus macaques, supporting its potential as a broad coronavirus vaccine strategy.