Regulation of hematopoietic stem cell (HSC) proliferation by Epithelial Growth Factor Like-7 (EGFL7)
Rohan SUDHIR Kulkarni, Chinmayee Goda, Alexander Rudich, Malith S. Karunasiri, Amog P. Urs, Yaphet Bustos, Ozlen Balcioglu, Wenjun Li, Sadie L. Chidester, Kyleigh A. Rodgers, Elizabeth A.R. Garfinkle, Ami B. Patel, Katherine E. Miller, Phillip G. Popovich, Shannon Elf, , Adrienne M. Dorrance
This study shows that EGFL7 promotes HSC expansion and survival, and its absence leads to reduced HSPC numbers and increased quiescence, with rEGFL7 treatment reversing these effects.
bioRxiv · Jan 21, 2025 · PreprintCell Biology