Spinal Cord Injury Imprints a Glucocorticoid-Driven Failure State in Hematopoietic Stem Cells
Kyleigh A. Rodgers, Elizabeth A.R. Garfinkle, Kristina A. Kigerl, Elham Asghari Adib, Katherine A. Mifflin, Jodie C.E. Hall, Rohan SUDHIR Kulkarni, Cankun Wang, Chinmayee Goda, Ana C Rodrigues Dias, Zhen Guan, Malith S. Karunasiri, Qin Ma, Katherine E. Miller, Adrienne M. Dorrance, Phillip G. Popovich
This paper shows spinal cord injury causes hematopoietic stem cells to enter a repressed state due to glucocorticoid surges, leading to long-term hematopoietic failure, which can be reversed by early glucocorticoid receptor blockade.
bioRxiv · Oct 5, 2025 · PreprintCell Biology