Adrienne M. Dorrance

Tirzepatide preserves hematopoietic stem and progenitor cycling while remodeling inflammatory monocytes in obese mice

This study compares the effects of tirzepatide and caloric restriction on hematopoiesis in obese mice, finding tirzepatide preserves HSPC cycling and reduces inflammatory monocytes while CR causes cytopenias.

circPCMTD1: A protein-coding circular RNA that regulates DNA damage response in BCR/ABL-positive leukemias

This study identifies circPCMTD1 as a circular RNA that promotes leukemic cell proliferation by enhancing DNA damage response tolerance through a novel peptide product.

Spinal Cord Injury Imprints a Glucocorticoid-Driven Failure State in Hematopoietic Stem Cells

This paper shows spinal cord injury causes hematopoietic stem cells to enter a repressed state due to glucocorticoid surges, leading to long-term hematopoietic failure, which can be reversed by early glucocorticoid receptor blockade.

Regulation of hematopoietic stem cell (HSC) proliferation by Epithelial Growth Factor Like-7 (EGFL7)

This study shows that EGFL7 promotes HSC expansion and survival, and its absence leads to reduced HSPC numbers and increased quiescence, with rEGFL7 treatment reversing these effects.