rbfox1 LoF mutants show disrupted bdnf/trkb2 and crhb/nr3c2 expression and increased cortisol levels during development coupled with signs of allostatic overload in adulthood
Adele Leggieri, Judit García‐González, Saeedeh Hosseinian, Peter Ashdown, Sofia Anagianni, Xian Wang, William Havelange, Noèlia Fernàndez-castillo A, Bru Cormand, Caroline H. Brennan
This study shows that rbfox1 loss of function in zebrafish disrupts stress-related gene expression and increases cortisol levels during development, leading to behavioral and physiological signs of allostatic overload in adulthood.
Translational Psychiatry · Nov 19, 2025Peer-reviewedGenetics