Author

Peter Ashdown

Queen Mary University of LondonORCID 0009-0003-3976-1333Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1 Organism:zebrafish· 1

Frequent Co-Authors

Adele LeggieriiD· 1 shared Bru CormandiD· 1 shared Caroline H. BrennaniD· 1 shared Dawn ThompsoniD· 1 shared Florentina NegoitaiD· 1 shared James N. HislopiD· 1 shared Judit García‐GonzáleziD· 1 shared Kei SakamotoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetics

Adele LeggieriORCID

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2 papers

Recent·Most cited

Cell BiologyBiochemical JournalPeer-reviewedAug 20, 2026

Substrate-specific regulation of the mTORC1 pathway by G protein-coupled receptors

Samuel J. Atkinson, Florentina Negoita, Yuichiro Ioi…·Riko Hatakeyama

This study shows that GPCRs regulate mTORC1 substrates differently, with M5R promoting protein synthesis while allowing lysosome biogenesis.

DOI 10.1042/bcj20260165

proteomicsexperimental assay

𝕏 PostBluesky

GeneticsTranslational PsychiatryPeer-reviewedNov 19, 2025

rbfox1 LoF mutants show disrupted bdnf/trkb2 and crhb/nr3c2 expression and increased cortisol levels during development coupled with signs of allostatic overload in adulthood

Adele Leggieri, Judit García‐González, Saeedeh Hosseinian…·Caroline H. Brennan

This study shows that rbfox1 loss of function in zebrafish disrupts stress-related gene expression and increases cortisol levels during development, leading to behavioral and physiological signs of allostatic overload in adulthood.

3 citations

zebrafishexperimental assay

𝕏 PostBluesky