Native receptor-targeted chemogenetics enables cell-type-specific inhibition of endogenous receptors in freely moving mice
Tomohiro Doura, Wataru Kakegawa, Keigo Morikawa, Tomoteru Yamasaki, Duy Phuoc Tran, Masayuki Fujinaga, Takumi Kondo, Shuntaro Kashiwa, Kanta Hasegawa, Eriko Miura, Saeko Matsudaira, Yuya Fujihara, Hiroshi Nonaka, Itaru Hamachi, Yuzaki Michisuke, , Shigeki Kiyonaka
This paper introduces NARCH, a chemogenetic method to reversibly inhibit endogenous receptors in specific cell types in vivo, demonstrating its use in studying mGlu1 signaling in Purkinje cells.
bioRxiv · Feb 24, 2026 · PreprintNeuroscience