Wataru Kakegawa

This paper introduces NARCH, a chemogenetic method to reversibly inhibit endogenous receptors in specific cell types in vivo, demonstrating its use in studying mGlu1 signaling in Purkinje cells.

This paper introduces a chemical probe for visualizing AMPA receptors in living neurons without genetic modification, revealing synaptic plasticity mechanisms.

This study develops a feeder-free method to efficiently generate mature excitatory neurons from human ES/iPS cells, showing high purity and functional characteristics relevant to neurodegenerative disease research.

This paper develops a chemogenetic method to selectively activate mGlu1 receptors in brain tissue using a palladium complex and a mutant receptor, demonstrating its role in synaptic plasticity.

The paper introduces FixEL, a method to trap and image small molecules in brain tissue, enabling visualization of their distribution and dynamics.

The paper designs and characterizes CPTX, a synthetic protein that restores synaptic function and behavior in mouse models of neurological diseases.