Tomohiro Doura

The paper introduces an off-target-free chemogenetic platform to study GPCR functions, demonstrating its application on the adenosine A2A receptor and showing its generalizability to other class A GPCRs.

This paper introduces NARCH, a chemogenetic method to reversibly inhibit endogenous receptors in specific cell types in vivo, demonstrating its use in studying mGlu1 signaling in Purkinje cells.

This paper develops a chemogenetic method to selectively activate mGlu1 receptors in brain tissue using a palladium complex and a mutant receptor, demonstrating its role in synaptic plasticity.