Michisuke Yuzaki

Ternary Neurexin-T178-PTPR complexes represent a presynaptic core-module of neuronal synapse organization

The paper identifies a presynaptic core-module composed of Neurexins, T178 tetraspanins, and PTPRs that organizes synaptic adhesion and signaling in the mammalian brain.

Native receptor-targeted chemogenetics enables cell-type-specific inhibition of endogenous receptors in freely moving mice

This paper introduces NARCH, a chemogenetic method to reversibly inhibit endogenous receptors in specific cell types in vivo, demonstrating its use in studying mGlu1 signaling in Purkinje cells.

Operant House: A Versatile Open-Source Platform for Automated Operant Conditioning Testing of Mice in Home Cages

Operant House is a low-cost, automated platform for operant conditioning testing in mice, revealing early working memory deficits in a Alzheimer's disease model.

A fluorophore-ligand conjugate for the rapid and reversible staining of native AMPA receptors in living neurons

This paper introduces a chemical probe for visualizing AMPA receptors in living neurons without genetic modification, revealing synaptic plasticity mechanisms.

Highly efficient induction of functionally mature excitatory neurons from feeder-free human ES/iPS cells

This study develops a feeder-free method to efficiently generate mature excitatory neurons from human ES/iPS cells, showing high purity and functional characteristics relevant to neurodegenerative disease research.

Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue

This paper develops a chemogenetic method to selectively activate mGlu1 receptors in brain tissue using a palladium complex and a mutant receptor, demonstrating its role in synaptic plasticity.

Activity-driven synaptic translocation of LGI1 controls excitatory neurotransmission

This study shows that neuronal activity drives the translocation of LGI1 and ADAM23 to the synaptic cleft, adjusting excitatory neurotransmission based on activity history.

Revisiting PFA-mediated tissue fixation chemistry: FixEL enables trapping of small molecules in the brain to visualize their distribution dynamics

The paper introduces FixEL, a method to trap and image small molecules in brain tissue, enabling visualization of their distribution and dynamics.

Subunit-dependent and independent rules of AMPA receptor trafficking during long-term depression in hippocampal neurons

The paper investigates how phosphorylation of GluA1 AMPAR subunits influences subunit-dependent and independent trafficking during LTD in hippocampal neurons.

A synthetic synaptic organizer protein restores glutamatergic neuronal circuits

The paper designs and characterizes CPTX, a synthetic protein that restores synaptic function and behavior in mouse models of neurological diseases.

Calsyntenin-3 directly interacts with neurexins to orchestrate excitatory synapse development in the hippocampus

This study shows that Calsyntenin-3 interacts with specific neurexin variants to promote excitatory synapse development in the hippocampus.