Hannan Mir

Targeting DNA Polymerase Epsilon Leads to Tumor Clearance and Activation of an NF-κB mediated inflammatory response in Triple Negative Breast Cancer

This study shows that inhibiting DNA polymerase epsilon in TNBC triggers an NF-κB-driven inflammatory response and tumor clearance in mice.

Acute inhibition of iron-sulfur cluster biosynthesis disrupts metabolic flexibility in mice

This study shows that acute inhibition of iron-sulfur cluster biosynthesis in mice leads to metabolic inflexibility, reduced adiposity, and glucose dyshomeostasis, with effects mitigated in aged mice.