Cell fate specification during respiratory development requires ARID1A-containing canonical BAF complex activity
Hyunwook Lee, Abigail Jaquish, Sharlene Fernandes, Barbara Zhao, Amber Elitz, Kathleen Cook, Sarah Trovillion, Natalia Bottasso-Arias, Simon J. Y. Han, Samantha Goodwin, Nicholas X. Russell, Gerald Saunders, Amanda L. Zacharias, Samantha A. Brugmann, Jeffrey A. Whitsett, , William J. Zacharias
The paper shows that the ARID1A-containing BAF complex is essential for lung development, proximal-distal axis specification, and cell fate acquisition during respiratory development.
Nature Communications · Apr 21, 2026Peer-reviewedDevelopmental Biology