Author

Natalia Bottasso-Arias

Cincinnati Children's Hospital Medical CenterORCID 0000-0002-3553-6978Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell-cell communication· 1 Approach:statistical model· 1

Frequent Co-Authors

Debora I. SinneriD· 3 shared Nicholas X. RusselliD· 3 shared Kaulini BurraiD· 2 shared Megha MohanakrishnaniD· 2 shared Sarah TrovillioniD· 2 shared Abigail JaquishiD· 1 shared Amanda L. ZachariasiD· 1 shared Amber Elitz· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersDevelopmental Biology

Debora I. SinnerORCID

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3 papers

Recent·Most cited

Cell fate specification during respiratory development requires ARID1A-containing canonical BAF complex activity

Hyunwook Lee, Abigail Jaquish, Sharlene Fernandes, Barbara Zhao, Amber Elitz, Kathleen Cook, Sarah Trovillion, Natalia Bottasso-Arias, Simon J. Y. Han, Samantha Goodwin, Nicholas X. Russell, Gerald Saunders, Amanda L. Zacharias, Samantha A. Brugmann, Jeffrey A. Whitsett, , William J. Zacharias

The paper shows that the ARID1A-containing BAF complex is essential for lung development, proximal-distal axis specification, and cell fate acquisition during respiratory development.

Nature Communications · Apr 21, 2026Peer-reviewedDevelopmental Biology

Wnt5a and Notum Influence the Temporal Dynamics of Cartilaginous Mesenchymal Condensations in Developing Trachea.

Natalia Bottasso-Arias, Megha Mohanakrishnan, Sarah Trovillion, Kaulini Burra, Nicholas X. Russell, Yixin Wu, Yan Juan Xu, Debora I. Sinner

This study investigates the role of Notum and Wnt5a in regulating the timing of cartilaginous mesenchymal condensations in developing trachea, showing their impact on chondrogenesis and tracheal lumen formation.

Frontiers in Cell and Developmental Biology · Apr 9, 2025Peer-reviewedDevelopmental Biology

Wnt signaling regulates ion channel expression to promote smooth muscle and cartilage formation in developing mouse trachea.

Nicholas X. Russell, Kaulini Burra, Ronak Shah, Natalia Bottasso-Arias, Megha Mohanakrishnan, John M. Snowball, Harshavardhana H. Ediga, Satish Kumar Madala, Debora I. Sinner

This study shows that Wnt signaling regulates ion channel expression, which is essential for trachealis muscle and cartilage development in mice.

American Journal of Physiology-Lung Cellular and Molecular Physiology · Oct 24, 2023Peer-reviewedDevelopmental Biology