Tissue-specific chromatin accessibility and co-factor availability together define ASCL1-dependent neural reprogrammability across germ layers during embryogenesis
David Lando, Samina Kausar, Toshiaki Shigeoka, Frances Connor, Jérôme Jullien, Anna Philpott
The paper shows that chromatin accessibility and co-factor availability determine ASCL1's ability to reprogram cells across different tissues in Xenopus embryos.
bioRxiv · Jul 14, 2026 · PreprintDevelopmental Biology