Chromatin priming and co-factor availability shape lineage response to the neuronal pioneer factor ASCL1 in pluripotency
Jethro Lundie-Brown, Rosalind Drummond, John-Poul Ng-Blichfeldt…·Anna Philpott
The paper shows that ASCL1's ability to induce a neuronal program in pluripotent cells depends on chromatin priming and co-factor availability, with PHOX2B enhancing neuronal differentiation.