Anna Philpott

The paper shows that chromatin accessibility and co-factor availability determine ASCL1's ability to reprogram cells across different tissues in Xenopus embryos.

The paper shows that ASCL1's ability to induce a neuronal program in pluripotent cells depends on chromatin priming and co-factor availability, with PHOX2B enhancing neuronal differentiation.

The paper compares ASCL1 interactomes in neuroblastoma cell lines to identify CDK2-Cyclin A2 as suppressors of differentiation in MYCN-amplified cells.

The paper uses human iPSC-derived 3D trunk-like structures to study mesodermal lineage decisions and identifies TBX6 and FOXC1/2 as key regulators in human trunk mesoderm diversification.

The paper shows ASCL1 controls distinct transcriptional programs in different cell cycle stages by binding chromatin at promoters and enhancers, with G1 arrest required for neuronal differentiation.