Irina Gutsche

Deinococcus radiodurans HU: a versatile architect of nucleoid structure and plasticity

This study investigates how DrHU in Deinococcus radiodurans organizes nucleoid structure through two DNA binding modes, leading to distinct 2D and 3D arrangements under different conditions.

Deltaviruses spread through a viral Trojan Horse

This study shows deltaviruses use helper virus particles as Trojan Horses for cell entry, revealing a new mode of viral transmission.

A single methylation site regulates HRSV nucleocapsid architecture and replication

This study identifies R27 methylation as a regulator of HRSV nucleocapsid structure and replication through molecular dynamics and cryo-EM analyses.

Expanding the Tubulin Code: TTLL11 Polyglutamylase Drives Elongation of Primary Tubulin Chains

This study identifies TTLL11 as a polyglutamylase that extends primary tubulin chains, revealing a new mechanism in the tubulin code and its interaction with other tubulin modifications.

Filamentation-driven peripheral clustering of the inducible lysine decarboxylase is crucial for E. coli acid stress response

This study shows that LdcI filamentation in E. coli drives peripheral clustering, enhancing acid stress response by spatially organizing the enzyme.

Combining live cell fluorescence imaging with in situ cryo electron tomography sheds light on the septation process in Deinococcus radiodurans

This study combines live cell fluorescence imaging and in situ cryo electron tomography to investigate the septation process in Deinococcus radiodurans, revealing insights into cell envelope architecture and molecular mechanisms of septal growth and closure.

blik: an extensible napari plugin for cryo-ET data visualisation, annotation and analysis

blik is an open-source napari plugin for visualizing, annotating, and analyzing cryo-ET data with extensibility and modularity.

The structural mechanism of MCIA complex assembly links mitochondrial redox pathways

This study reveals the structural mechanism of MCIA complex assembly, showing how ECSIT and ACAD9 interact to facilitate Complex I biogenesis and links ECSIT phosphorylation to Alzheimer's disease pathology.

De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals

The paper determines the structures of Cry11Aa and Cry11Ba toxins using serial femtosecond crystallography, revealing new insights into their in vivo crystallization patterns and toxicity.

Supramolecular assembly of the E. coli LdcI upon acid stress

This paper investigates the acid-stress response of E. coli LdcI using cryo-EM and super-resolution imaging, revealing its supramolecular assembly and proposing a mechanistic model for its function.