Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures
Christine Roden, Yifan Dai, Catherine A. Giannetti, Ian Seim, Myungwoon Lee, Rachel S. G. Sealfon, Grace A. McLaughlin, Mark A. Boerneke, Christiane Iserman, Samuel A Wey, Joanne L. Ekena, Olga G. Troyanskaya, Kevin M. Weeks, Lingchong You, Ashutosh Chilkoti, Amy S. Gladfelter
This study shows that SARS-CoV-2 N-protein uses two distinct RNA motifs, both requiring dsRNA, to drive phase separation at specific temperatures, enabling multiple viral functions.
Nucleic Acids Research · Jul 24, 2022Peer-reviewedMolecular Biology