Rachel S. G. Sealfon

Atlas of glomerular disease-specific genetic effects on blood transcriptome

The paper generates disease-specific genetic effect maps on the blood transcriptome for five glomerular diseases using whole genome and transcriptome sequencing data from the CureGN cohort.

Cellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human Kidney

The paper presents a multi-modal atlas of human kidney disease, identifying cellular and spatial mechanisms of injury resolution or failure and linking them to clinical outcomes.

Biomolecular condensates control and are defined by RNA-RNA interactions that arise in viral replication

The paper investigates how RNA-RNA interactions in viral replication are controlled by biomolecular condensates, showing that sequence complementarity and condensate properties influence RNA organization.

Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures

This study shows that SARS-CoV-2 N-protein uses two distinct RNA motifs, both requiring dsRNA, to drive phase separation at specific temperatures, enabling multiple viral functions.

A reference tissue atlas for the human kidney

The paper constructs a reference tissue atlas of the human kidney using multi-omics data to identify cell types, pathways, and genes across nephron segments and interstitium.

SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes

The paper identifies a high-confidence SARS-CoV-2 gene set and analyzes evolutionary constraints and mutation impacts across 44 Sarbecovirus genomes.

Decomposing cell identity for transfer learning across cellular measurements, platforms, tissues, and species.

The paper introduces scCoGAPS and projectR to decompose cell identity into shared and species-specific factors, enabling transfer learning across datasets and species.