Author

Sandra Byju

Northeastern University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Organism:multiple species· 1

Frequent Co-Authors

Paul C. WhitfordiD· 3 shared Asem H. HassaniD· 1 shared Christine M. DunhamiD· 1 shared Claude Roc· 1 shared Daniel Joseph DeredgeiD· 1 shared Evelyn M. KimbroughiD· 1 shared Fabrizio MarinelliiD· 1 shared Frederico Campos FreitasiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBiophysics

Paul C. WhitfordORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Multi-Ensemble Reweighting Enables Structural Interpretation of Differential HDX-MS

Sandra Byju, Vincent M. Lowe, Daniel Joseph Deredge, Fabrizio Marinelli

This paper introduces a multi-ensemble reweighting method for HDX-MS data to improve structural interpretation by accounting for deuterium loss, showing better accuracy than conventional methods.

bioRxiv · Oct 29, 2026 · PreprintBiophysics

Characterization of a potential antibiotic target site on the ribosome

Michael Golstein, Yang Wang, Sandra Byju, Udayan Mohanty, Paul C. Whitford

The paper identifies a novel antibiotic target site on the bacterial ribosome by showing how small molecules binding to ribosomal protein L33 can impede translation through steric obstruction.

bioRxiv · May 2, 2025 · PreprintBiophysics

How subunit rotation controls tRNA dynamics in the ribosome

Sandra Byju, Paul C. Whitford

This study uses molecular simulations to show that subunit rotation in the ribosome non-monotonically affects tRNA kinetics, driven by steric contributions from a single ribosomal protein.

bioRxiv · Jan 22, 2025 · PreprintBiophysics

Ratchet, swivel, tilt and roll: A complete description of subunit rotation in the ribosome

Asem H. Hassan, Sandra Byju, Frederico Campos Freitas, Claude Roc, Nisaa Pender, Kien Nguyen, Evelyn M. Kimbrough, Jacob M. Mattingly, Ruben L. Gonzalez, Ronaldo Junio de Oliveira, Christine M. Dunham, Paul C. Whitford

The paper introduces the RAD method to quantitatively describe subunit rotations in ribosomes and applies it to analyze ribosome structures across organisms.

Nucleic Acids Research · Dec 7, 2022Peer-reviewedMolecular Biology