Reconstructing stochastic cell population trajectories reveals regulators and heterogeneity of endothelial flow-migration coupling driving vascular remodelling
Wolfgang Giese, André Rosa, Elisabeth Baumann, Olya Oppenheim, Emir Bora Akmeriç, Santiago Andrade, Irene Hollfinger, Eireen Bartels‐Klein, Silvanus Alt, Holger Gerhardt
The paper develops a computational model to analyze EC migration during vascular remodelling, finding that directional migration is driven by dual force fields and mediated by Cdc42 with cell population heterogeneity.
bioRxiv · May 30, 2023 · PreprintDevelopmental Biology