Reconstructing stochastic cell population trajectories reveals regulators and heterogeneity of endothelial flow-migration coupling driving vascular remodelling
Wolfgang Giese, André Rosa, Elisabeth Baumann…·Holger Gerhardt
The paper develops a computational model to analyze EC migration during vascular remodelling, finding that directional migration is driven by dual force fields and mediated by Cdc42 with cell population heterogeneity.