BAF complex-independent gene activation by SS18::SSX
Afroditi Sotiriou, Jinxiu Li, Sanya Middha, Jake A. Ward, Selina Troester, Lianghao Mao, Martin Schneider, Dario L. Frey, Eliza C. Wray, Sara Bocedi, Kyllie Smith-Fry, Linda C. Morrison, Lara S. Carroll, Mihaly Badonyi, Joseph A. Marsh, , Ana Banito
This study shows that SS18::SSX can drive transcription independently of BAF complex interaction and relies on EP300 for gene activation, suggesting new therapeutic targets for synovial sarcoma.
bioRxiv · Jan 27, 2026 · PreprintCancer Biology