Lara S. Carroll

BAF complex-independent gene activation by SS18::SSX

This study shows that SS18::SSX can drive transcription independently of BAF complex interaction and relies on EP300 for gene activation, suggesting new therapeutic targets for synovial sarcoma.

SS18::SSX redistributes BAF chromatin remodelers selectively to activate and repress transcription

This paper shows SS18::SSX fusion protein alters BAF chromatin remodeler distribution, leading to transcriptional activation and repression by changing histone modifications at regulatory regions.

Start codon disruption with CRISPR/Cas9 prevents murine Fuchs' endothelial corneal dystrophy

This study shows that CRISPR/Cas9 gene editing in adult mice prevents vision loss in a model of Fuchs' endothelial corneal dystrophy by disrupting the start codon of the mutant COL8A2 gene.

Rod phototransduction and light signal transmission during type 2 diabetes

This study investigates how type 2 diabetes affects rod photoreceptor function in vivo and ex vivo, finding that long-term diabetes impairs glucose-induced responses but not intrinsic light signal transduction.

Loss of Corneal Raver2 Expression in Aniridia Associated Keratopathy

This study identifies Raver2 as a downstream factor of Pax6 in corneal development, showing its downregulation in aniridia-associated keratopathy in mice and humans.