Author

Kyllie Smith-Fry

University of Utah

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Assay:DNA methylation· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Kevin B. JonesiD· 3 shared Afroditi SotiriouiD· 2 shared Ana BanitoiD· 2 shared Bradley Robert CairnsiD· 2 shared Lara S. CarrolliD· 2 shared Li LiiD· 2 shared Linda C. MorrisoniD· 2 shared Alexandros C. DimopoulosiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCancer Biology

Kevin B. JonesORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BAF complex-independent gene activation by SS18::SSX

Afroditi Sotiriou, Jinxiu Li, Sanya Middha, Jake A. Ward, Selina Troester, Lianghao Mao, Martin Schneider, Dario L. Frey, Eliza C. Wray, Sara Bocedi, Kyllie Smith-Fry, Linda C. Morrison, Lara S. Carroll, Mihaly Badonyi, Joseph A. Marsh, , Ana Banito

This study shows that SS18::SSX can drive transcription independently of BAF complex interaction and relies on EP300 for gene activation, suggesting new therapeutic targets for synovial sarcoma.

bioRxiv · Jan 27, 2026 · PreprintCancer Biology

Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in Synovial Sarcoma

Konstantinos V. Floros, Carter K. Fairchild, Jinxiu Li, Kun Zhang, Jane L. Roberts, Richard Kurupi, Durga Paudel, Yanli Xing, Bin Hu, Vita Kraskauskiene, Nayyerehalsadat Hosseini, Shanwei Shen, Melissa M. Inge, Kyllie Smith-Fry, Li Li, , Anthony C. Faber

This study shows that inhibiting SUMOylation with TAK-981 stabilizes cBAF complexes and disrupts the SS18::SSX-driven transcriptome in synovial sarcoma, leading to tumor inhibition.

Nature Communications · Nov 5, 2025Peer-reviewedCancer Biology

SS18::SSX redistributes BAF chromatin remodelers selectively to activate and repress transcription

Jinxiu Li, Li Li, Kyllie Smith-Fry, Zaki F. Wilmot, Lara S. Carroll, Linda C. Morrison, Xinyi Ge, Mary Nelson, Lesley A. Hill, Xiaoyang Zhang, Torsten O. Nielsen, Martin Hirst, T. Michael Underhill, Bradley Robert Cairns, Kevin B. Jones

This paper shows SS18::SSX fusion protein alters BAF chromatin remodeler distribution, leading to transcriptional activation and repression by changing histone modifications at regulatory regions.

bioRxiv · May 14, 2024 · PreprintCancer Biology