CD33-CD45 Interaction Reveals a Mechanistic Link to Alzheimer's Disease Susceptibility
Nicole Vo, Cory D. Rillahan, Zena K. Chatila, Daniel M. Virga, Jennifer L. Hall, Kirstin A. Tamucci, Mamunur Rashid, Sarah M. Connor, Sana Chintamen, Gaelen Guzman, Mariko F. Taga, Minghua Liu, Philip L. De Jager, Peter St George‐Hyslop, Annie Lee, , Elizabeth M. Bradshaw
This study identifies CD45 as a sialic acid-dependent binding partner of CD33, showing that their interaction contributes to Alzheimer's disease susceptibility through impaired microglial function.
bioRxiv · Jul 28, 2025 · PreprintNeuroscience