Mitochondrial antigen-specific CD8⁺ T cells drive dopamine neuron neurodegeneration
Moustafa Nouh Elemeery, Alex Tchung, Salix Boulet, Nicolas Giguère, Sarah Mezrag, Jean‐François Daudelin, Amandine Even, Abigail Ralph, Sriparna Mukherjee, Claudie Beaulieu, Diana Matheoud, Jo-Ann Stratton, Nathalie Labrecque, Louis‐Éric Trudeau
This study shows that mitochondrial antigen-specific CD8+ T cells can induce nigrostriatal dysfunction and dopamine neuron degeneration in mice, supporting an immune-driven mechanism in Parkinson's disease.
bioRxiv · Feb 26, 2024 · PreprintNeuroscience