Nathalie Labrecque

This study identifies IL-17RD as a negative regulator of RIG-I-like receptor-dependent antiviral immunity, showing it limits SARS-CoV-2-induced lung inflammation.

This study shows that Notch signaling regulates CD8+ T cell exhaustion and differentiation during chronic infection by promoting the transition from progenitor to effector-like cells and preventing terminal exhaustion.

This study shows NR4A3 is not required for generating CD8+ resident memory T cells in epithelial or non-epithelial sites, unlike NR4A1 and NR4A2.

This study shows that mitochondrial antigen-specific CD8+ T cells can induce nigrostriatal dysfunction and dopamine neuron degeneration in mice, supporting an immune-driven mechanism in Parkinson's disease.

This study shows that Helicobacter pylori infection in Pink1-/- mice causes motor and cognitive dysfunction linked to CD8 T cell activity, mimicking early PD features.