Context-dependent NMDA receptor dysfunction predicts seizure treatment in mice with human GluN1 variant
Sridevi Venkatesan, Daria Nazarkina, Megan T. Sullivan, Yao‐Fang Tan, Sarah Qu, Amy J. Ramsey, Evelyn K. Lambe
The paper shows that a GluN1 variant causes NMDAR dysfunction in mice, leading to seizures, and demonstrates that boosting negative feedback can treat them.
iScience · Dec 1, 2025Peer-reviewedNeuroscience