JoAnne McLaurin

Aberrant cortical reorganization and astrogliosis underlie memory deficit post-traumatic brain injury: a longitudinal multiscale multimodal study

This study uses multiscale multimodal data integration in a mouse model of traumatic brain injury to identify biomarkers of memory deficits and network dedifferentiation.

Stable neuronal representations to repeated stimulation underlie cognitive resilience in Alzheimer's disease pathology

The paper identifies stable neuronal representations in cognitively resilient Alzheimer's disease rats during repeated stimulation, suggesting a potential biomarker for cognitive resilience.

Quantitative profiling of whole-brain connectomes at single-axon resolution using deep learning and high-resolution light sheet microscopy

This paper introduces MAPL3, a deep learning pipeline for mapping whole-brain connectomes at single-axon resolution, demonstrating its effectiveness in analyzing orbitofrontal cortex circuitry.

NEUROG2 regulates a human-specific neurodevelopmental gene regulatory program

The paper identifies NEUROG2's role in regulating a human-specific gene regulatory program in neural progenitor cells through transcriptomic analysis of knock-in organoids.

Enhanced prefrontal nicotinic signaling as evidence of active compensation in Alzheimer's disease models

The paper shows enhanced nicotinic signaling in prefrontal cortex of AD models, which can be amplified by nicotinic receptor modulation without altering kinetics.

Unveiling the Structural Proteome of an Alzheimer's Disease Rat Brain Model

This study uses cryo-EM and BaR to analyze protein complexes in an Alzheimer's rat brain model, revealing structural insights relevant to multiple diseases.

Obesity differentially effects the somatosensory cortex and striatum of TgF344-AD rats

This study shows that obesity affects myelination differently in the somatosensory cortex and striatum of TgF344-AD rats, explaining the obesity paradox in AD.

CHRNA5 links chandelier cells to severity of amyloid pathology in human aging and Alzheimer's Disease

The paper investigates CHRNA5's role in amyloid pathology in aging and Alzheimer's by analyzing genetic variants and cell-type expression in human brain tissue.

A Deep Learning Pipeline for Mapping in situ Network-level Neurovascular Coupling in Multi-photon Fluorescence Microscopy

The paper develops a deep learning pipeline to analyze microvascular network changes in response to neuronal activity using two-photon microscopy, revealing network-level coordination in blood flow adjustments.

Obesity Facilitates Sex-Specific Improvement In Cognition And Neuronal Function In A Rat Model Of Alzheimer's Disease

This study shows obesity in early symptomatic AD rats improves cognition and myelin but worsens amyloid-beta and tau pathology, with stronger effects in females.