Evelyn K. Lambe

Spacing theta-burst stimulation enhances synaptic potentiation in the vulnerable prefrontal cortex

The paper shows that spaced theta-burst stimulation enhances synaptic potentiation in the prefrontal cortex of socially isolated mice.

Characterization of the Grin1Q536R/+ mouse: a preclinical model for GRIN1-related neurodevelopmental disorder

The paper characterizes a Grin1Q536R/+ mouse model carrying a GRIN1 variant, showing age- and sex-dependent behavioral and physiological changes linked to GRIN1-NDD.

Context-dependent NMDA receptor dysfunction predicts seizure treatment in mice with human GluN1 variant

The paper shows that a GluN1 variant causes NMDAR dysfunction in mice, leading to seizures, and demonstrates that boosting negative feedback can treat them.

Enhanced prefrontal nicotinic signaling as evidence of active compensation in Alzheimer's disease models

The paper shows enhanced nicotinic signaling in prefrontal cortex of AD models, which can be amplified by nicotinic receptor modulation without altering kinetics.

β-hydroxybutyrate improves convulsions in mice carrying the GRIN1 Y647S/+ pathogenic variant

This study investigates the effects of the GRIN1 Y647S variant in mice, showing that β-hydroxybutyrate reduces convulsions associated with the variant.

CHRNA5 links chandelier cells to severity of amyloid pathology in human aging and Alzheimer's Disease

The paper investigates CHRNA5's role in amyloid pathology in aging and Alzheimer's by analyzing genetic variants and cell-type expression in human brain tissue.

Ventral hippocampal CCK interneurons gate context-reward memory

The paper identifies CCK interneurons in the ventral hippocampus that regulate context-reward memory through their influence on vHPC-NAc circuit activity.

Medial Prefrontal Cortex Serotonin Input Regulates Cognitive Flexibility in Mice

This study shows that serotonin release from dorsal raphe-to-mPFC neurons modulates cognitive flexibility in mice by enhancing extradimensional rule shift performance.

Xanomeline restores endogenous nicotinic acetylcholine receptor signaling in mouse prefrontal cortex

This study shows that xanomeline restores age-related nicotinic signaling deficits in mouse prefrontal cortex by enhancing muscarinic receptor pathways and nicotinic receptor availability.

Deficits in integrative NMDA receptors caused by Grin1 disruption can be rescued in adulthood

This study shows that deficits in extrasynaptic NMDARs caused by Grin1 disruption can be rescued in adult mice through genetic intervention.

Chrna5 and lynx prototoxins identify acetylcholine super-responder subplate neurons

The paper identifies Chrna5-expressing super-responder subplate neurons using transgenic mice and single-cell transcriptomics, revealing unique lynx prototoxin gene expression and potential therapeutic targets for attention disorders.

Chrna5 is essential for a rapid and protected response to optogenetic release of endogenous acetylcholine in prefrontal cortex

This study shows that Chrna5 enables rapid and resilient cholinergic responses in prefrontal cortex, crucial for attention, and identifies NS9283 as a potential treatment for Chrna5 disruption.

Consequences Of NMDA Receptor Deficiency Can Be Rescued In The Adult Brain

This study shows that restoring NMDAR function in adult mice with congenital NMDAR deficiency improves cognitive behaviors, suggesting potential for adult treatment of related disorders.