Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53
Kim Wendrich, Kai Gallant, Sarah Recknagel, Stavroula Petroulia, Nafizul Haque Kazi, Jan André Hane, Siska Führer, Karel Bezstarosti, Rachel O’Dea, Jeroen Demmers, Malte Gersch
This study identifies USP53 and USP54 as active deubiquitinases specific for K63-linked polyubiquitin, revealing their role in regulating tricellular junctions and correcting previous annotations of them as pseudo-enzymes.
Nature Chemical Biology · Nov 25, 2024Peer-reviewedBiochemistry