Author

Kai Gallant

TU Dortmund UniversityORCID 0000-0003-0884-8156Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Malte GerschiD· 2 shared Nafizul Haque KaziiD· 2 shared Gian‐Marvin KipkaiD· 1 shared Jan André HaneiD· 1 shared Jeroen DemmersiD· 1 shared Karel Bezstarosti· 1 shared Kim WendrichiD· 1 shared Nikolas KlinkiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Malte GerschORCID

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2 papers

Recent·Most cited

BiochemistryNature Structural & Molecular BiologyPeer-reviewedMay 5, 2025

Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of USP30 and a framework for DUB ligandability

Nafizul Haque Kazi, Nikolas Klink, Kai Gallant…·Malte Gersch

This study identifies the structural basis for USP30 inhibition using chimeric protein engineering and provides a framework for designing specific deubiquitinase inhibitors.

26 citationstop 2%

humanstructural biology

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BiochemistryNature Chemical BiologyPeer-reviewedNov 25, 2024

Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53

Kim Wendrich, Kai Gallant, Sarah Recknagel…·Malte Gersch

This study identifies USP53 and USP54 as active deubiquitinases specific for K63-linked polyubiquitin, revealing their role in regulating tricellular junctions and correcting previous annotations of them as pseudo-enzymes.

28 citations

humanproteomics

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