Author

Jan André Hane

The University of MelbourneORCID 0009-0008-8752-884XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Assay:proteomics· 2 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Malte GerschiD· 2 shared Anthony CerraiD· 1 shared David KomanderiD· 1 shared Jack A Alexandrovics· 1 shared Jeffrey J. BaboniD· 1 shared Jeroen DemmersiD· 1 shared Kai GallantiD· 1 shared Karel Bezstarosti· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Malte GerschORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedJul 17, 2026

ZnF-UBP domains regulate deubiquitinase activity by relieving ubiquitin product inhibition

Jack A Alexandrovics, Rashmi Agrata, Jan André Hane…·David Komander

The paper investigates ZnF-UBP domains in USP DUBs, showing they relieve product inhibition by facilitating Ub release, thereby regulating enzyme activity.

1 citation

humanproteomics

𝕏 PostBluesky

BiochemistryNature Chemical BiologyPeer-reviewedNov 25, 2024

Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53

Kim Wendrich, Kai Gallant, Sarah Recknagel…·Malte Gersch

This study identifies USP53 and USP54 as active deubiquitinases specific for K63-linked polyubiquitin, revealing their role in regulating tricellular junctions and correcting previous annotations of them as pseudo-enzymes.

28 citations

humanproteomics

𝕏 PostBluesky