Author

Nafizul Haque Kazi

TU Dortmund UniversityORCID 0009-0004-3775-1497Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Kai GallantiD· 2 shared Malte GerschiD· 2 shared Gian‐Marvin KipkaiD· 1 shared Jan André HaneiD· 1 shared Jeroen DemmersiD· 1 shared Karel Bezstarosti· 1 shared Kim WendrichiD· 1 shared Nikolas KlinkiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Kai GallantORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of USP30 and a framework for DUB ligandability

Nafizul Haque Kazi, Nikolas Klink, Kai Gallant, Gian‐Marvin Kipka, Malte Gersch

This study identifies the structural basis for USP30 inhibition using chimeric protein engineering and provides a framework for designing specific deubiquitinase inhibitors.

Nature Structural & Molecular Biology · May 5, 2025Peer-reviewedBiochemistry

Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53

Kim Wendrich, Kai Gallant, Sarah Recknagel, Stavroula Petroulia, Nafizul Haque Kazi, Jan André Hane, Siska Führer, Karel Bezstarosti, Rachel O’Dea, Jeroen Demmers, Malte Gersch

This study identifies USP53 and USP54 as active deubiquitinases specific for K63-linked polyubiquitin, revealing their role in regulating tricellular junctions and correcting previous annotations of them as pseudo-enzymes.

Nature Chemical Biology · Nov 25, 2024Peer-reviewedBiochemistry