Malte Gersch

The paper investigates ZnF-UBP domains in USP DUBs, showing they relieve product inhibition by facilitating Ub release, thereby regulating enzyme activity.

This paper compares the effects of USP7 inhibition and degradation in cancer cells, finding distinct phenotypic and proteomic responses.

The paper identifies iDegs, which enhance IDO1 degradation via the native CRL2KLHDC3 pathway, reducing kynurenine formation and offering new therapeutic potential for cancer.

This study identifies the structural basis for USP30 inhibition using chimeric protein engineering and provides a framework for designing specific deubiquitinase inhibitors.

This study identifies USP53 and USP54 as active deubiquitinases specific for K63-linked polyubiquitin, revealing their role in regulating tricellular junctions and correcting previous annotations of them as pseudo-enzymes.