Author

Sarah Toay

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Yuri V. SergeeviD· 2 shared Brian P. BrooksiD· 1 shared Charles DeYoungiD· 1 shared Cuilee ShaiD· 1 shared David R. AdamsiD· 1 shared Diksha Shukla· 1 shared Jonathan Hale ZippiniD· 1 shared Joseph Bonica· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPharmacology & Toxicology

Yuri V. SergeevORCID

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2 papers

Recent·Most cited

Ampyrone (4-Aminoantipyrine) is a Direct Agonist of Human Tyrosinase and Potential Therapeutic for Oculocutaneous Albinism and Disorders of Hypopigmentation.

Monika B. Dolinska, Yuhong Wang, Nathan P. Coussens, Vijay K. Kalaskar, Zuhal Eraslan, Samuel J. Grondin, Joseph Bonica, Sarah Toay, Matthew D. Hall, Min Shen, Matthew B. Boxer, Qiuying Chen, Steven S. Gross, Nabeel Attarwala, Yingyos Jittayasothorn, , Brian P. Brooks

The paper identifies ampyrone as a direct activator of human tyrosinase, showing increased catalytic activity and melanin synthesis in melanocytes and skin cultures, suggesting potential therapeutic use for hypopigmentation disorders.

bioRxiv · Oct 13, 2025 · PreprintPharmacology & Toxicology

Genetic mutations disrupt the coordinated mode of tyrosinase's intra-melanosomal domain.

Sarah Toay, Yuri V. Sergeev

This study uses molecular dynamics and PCA to analyze coordinated movements in tyrosinase subdomains, showing mutations disrupt stability by disrupting helix coordination.

bioRxiv · Apr 21, 2025 · PreprintBiophysics