Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits
Aysegul O. Gezer, Joseph J. Kochmanski, Sarah VanOeveren, Allyson Cole-Strauss, Christopher J. Kemp, Joseph R. Patterson, Kathryn M. Miller, Nathan C. Kuhn, Danielle E. Herman, Alyssa McIntire, Jack W. Lipton, Kelvin C. Luk, Sheila M. Fleming, Caryl E. Sortwell, Alison I. Bernstein
This study shows that developmental dieldrin exposure increases male-specific motor deficits and dopamine handling issues in a synucleinopathy model, without affecting nigral neuron loss.
Neurobiology of Disease · May 15, 2020Peer-reviewedNeuroscience