Alison I. Bernstein

The paper identifies PD-associated shifts between 5-methylcytosine and 5-hydroxymethylcytosine in human brain tissue, linking them to genes involved in neuroinflammation and neurodevelopment.

This study shows that developmental exposure to dieldrin causes sex-specific DNA modifications in neurodevelopmental pathways, potentially increasing Parkinson's disease risk later in life.

This study shows that developmental exposure to dieldrin worsens dopamine-related deficits in mice with synucleinopathy, suggesting environmental factors contribute to Parkinson's disease progression.

The paper reports sex-specific DNA methylation changes in Parkinson's disease-associated genes in cortical neurons from post-mortem parietal cortex samples.

This study shows that developmental dieldrin exposure increases male-specific motor deficits and dopamine handling issues in a synucleinopathy model, without affecting nigral neuron loss.

The paper proposes a statistical method to analyze paired 5-mC and 5-hmC data at base-pair resolution to assess experimental treatment effects.