Nathan C. Kuhn

WAC loss alters food-associated behavior and physiological homeostasis with stage-associated cholinergic dysregulation in Caenorhabditis elegans

This study investigates the effects of wac deficiency in C. elegans on behavior, physiology, and cholinergic pathways, finding stage-specific transcriptional changes and functional interactions with cho-1.

Complement Dysregulation During the Early Phases of Synucleinopathy

This study shows that synucleinopathy triggers complement activation and dysregulation before neurodegeneration in a rat model and human Parkinson's disease tissue.

Neurobehavioral impacts of the autism risk gene, WAC: Studies involving C. elegans and Mice

This paper investigates the neurobehavioral impacts of the autism risk gene WAC in C. elegans and mice, finding altered neurotransmitter systems and gene expression patterns.

Parkinson's disease-associated shifts between DNA methylation and DNA hydroxymethylation in human brain

The paper identifies PD-associated shifts between 5-methylcytosine and 5-hydroxymethylcytosine in human brain tissue, linking them to genes involved in neuroinflammation and neurodevelopment.

Brief report on differential toxicity of legacy and second-generation PFAS on dopaminergic neurons and mitochondria

This study compares the neurotoxicity and mitochondrial effects of legacy and second-generation PFAS using C. elegans and rat brain mitochondria, finding distinct mechanisms between the two classes.

γ-glutamyl-cysteine is the critical intermediate in glutathione-modulated amelioration of PFOS-neurotoxicity

This study identifies γ-glutamyl-cysteine as the critical intermediate in GSH-mediated neuroprotection against PFOS toxicity in C. elegans.

Developmental origins of Parkinson's disease risk: perinatal exposure to the organochlorine pesticide dieldrin leads to sex-specific DNA modifications in critical neurodevelopmental pathways in the mouse midbrain

This study shows that developmental exposure to dieldrin causes sex-specific DNA modifications in neurodevelopmental pathways, potentially increasing Parkinson's disease risk later in life.

Developmental exposure to the Parkinson's disease-associated organochlorine pesticide dieldrin alters dopamine neurotransmission in α-synuclein pre-formed fibril (PFF)-injected mice

This study shows that developmental exposure to dieldrin worsens dopamine-related deficits in mice with synucleinopathy, suggesting environmental factors contribute to Parkinson's disease progression.

Parkinson's Disease-Associated, Sex-specific Changes in DNA Methylation at PARK7 (DJ-1), ATXN1, SLC17A6, NR4A2, and PTPRN2 in Cortical Neurons

The paper reports sex-specific DNA methylation changes in Parkinson's disease-associated genes in cortical neurons from post-mortem parietal cortex samples.

Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits

This study shows that developmental dieldrin exposure increases male-specific motor deficits and dopamine handling issues in a synucleinopathy model, without affecting nigral neuron loss.