Joseph J. Kochmanski

Parkinson's disease-associated shifts between DNA methylation and DNA hydroxymethylation in human brain

The paper identifies PD-associated shifts between 5-methylcytosine and 5-hydroxymethylcytosine in human brain tissue, linking them to genes involved in neuroinflammation and neurodevelopment.

Developmental origins of Parkinson's disease risk: perinatal exposure to the organochlorine pesticide dieldrin leads to sex-specific DNA modifications in critical neurodevelopmental pathways in the mouse midbrain

This study shows that developmental exposure to dieldrin causes sex-specific DNA modifications in neurodevelopmental pathways, potentially increasing Parkinson's disease risk later in life.

Parkinson's Disease-Associated, Sex-specific Changes in DNA Methylation at PARK7 (DJ-1), ATXN1, SLC17A6, NR4A2, and PTPRN2 in Cortical Neurons

The paper reports sex-specific DNA methylation changes in Parkinson's disease-associated genes in cortical neurons from post-mortem parietal cortex samples.

Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits

This study shows that developmental dieldrin exposure increases male-specific motor deficits and dopamine handling issues in a synucleinopathy model, without affecting nigral neuron loss.

Reconciling Base-Pair Resolution 5-methylcytosine and 5-hydroxymethylcytosine Data in Neuroepigenetics

The paper proposes a statistical method to analyze paired 5-mC and 5-hmC data at base-pair resolution to assess experimental treatment effects.