Caryl E. Sortwell

This study shows that synucleinopathy triggers complement activation and dysregulation before neurodegeneration in a rat model and human Parkinson's disease tissue.

This study examines how the rs6265 polymorphism affects the effectiveness of therapeutic electrical stimulation in peripheral nerve regeneration using rat models and human motor neurons.

This study shows that developmental exposure to dieldrin worsens dopamine-related deficits in mice with synucleinopathy, suggesting environmental factors contribute to Parkinson's disease progression.

This study shows that developmental dieldrin exposure increases male-specific motor deficits and dopamine handling issues in a synucleinopathy model, without affecting nigral neuron loss.

This study shows that overexpressing Nurr1 in the striatum of rats induces LID and worsens dyskinesia, suggesting Nurr1 as a therapeutic target for Parkinson’s disease.

This paper demonstrates that antisense oligonucleotides targeting SNCA reduce alpha-synuclein production, prevent pathology, and show translational potential in non-human primates.