Viscoelasticity driven deformation dynamics of the substrate affect mechanically induced Ca2+ signals
Heidi Peussa, Sari Peltola, Aapo Tervonen, Suvi Lehtimäki, Maija Kauppila, R Bhati, Chiara Fedele, H Tran, Elina Mäntylä, Arri Priimägi, Soile Nymark, Teemu O. Ihalainen
This study shows that substrate viscoelasticity influences how cells sense mechanical deformation through calcium signals, with stiff substrates producing stronger responses and distinct force dynamics.
bioRxiv · Nov 7, 2025 · PreprintCell Biology