Multi-omic profiling of human thymic B cells reveals intrathymic Ig-class switching and differentiation into multiple memory B cell subsets
Martijn Cordes, Erik B. van den Akker, Janine E. Melsen, Saskia Bunschuh, Aline Zbinden, Sandra de Bruin-Versteeg, Nannan Guo, Frits Koning, Szymon M. Kiełbasa, Karin Pike‐Overzet, Mirjam van der Burg, Marcel J. T. Reinders, Frank J. T. Staal, Kirsten Canté-Barrett
The paper identifies and characterizes distinct B cell subsets in the human thymus, revealing their development, differentiation, and class switching capabilities.
bioRxiv · May 26, 2026 · PreprintImmunology