Pradeep Chopra

A long-chain heparan sulfate capture mechanism directs paracrine GDNF-GFRα1 signalling through RET

The paper reveals how long-chain heparan sulfate (HS) facilitates paracrine GDNF-GFRα1 signaling by forming a multi-protein complex with RET, essential for signaling in trans but not in cis.

Structural insights into antibody responses against influenza A virus in its natural reservoir

This study characterizes antibody responses to H3 influenza A virus in mallard ducks, revealing unique features compared to human antibodies and highlighting gene conversion in antibody evolution.

Vaccine-induced antigenic drift of a human-origin H3N2 Influenza A virus in swine alters glycan binding and sialic acid avidity

This study shows vaccine-induced immunity drives antigenic drift in a human-origin H3N2 virus in swine, altering HA receptor binding and glycan specificity.

Cell-Surface RNA Forms Ternary Complex with RNA-Binding Proteins and Heparan Sulfate to Recruit Immune Receptors

The paper identifies heparan sulfate (HS) as a key factor for cell-surface RNA (csRNA) presentation and reveals a ternary complex of HS, RNA, and RNA-binding proteins that recruits immune receptors.

A Light Sensitive Hyaluronic Acid-based Hydrogel for 3D Culturing, Differentiation, and Harvesting of Mesenchymal Stromal Cells

This paper introduces a light-sensitive hyaluronic acid hydrogel for 3D cell culturing, differentiation, and harvesting of mesenchymal stromal cells, showing it can modulate cell behavior through light exposure.

Chemoenzymatic Synthesis of Asymmetric Bisecting Bi-, Tri-, and Tetra-Antennary N-Glycans

This paper develops a chemoenzymatic method to synthesize asymmetrical bisecting N-glycans and investigates their binding properties with lectins and influenza viruses.

Receptor Binding Specificity of a Bovine A(H5N1) Influenza Virus

The paper examines the receptor-binding specificity of a bovine HPAI H5N1 virus using multiple assays and finds it preferentially binds avian-type receptors.