Lead (Pb) exposure alters neural cell fate in the developing human brain
Maureen McGuirk Sampson, Sayli Sonsurkar, Lisa Nieland, Lin Pan, Ryan L. Kan, Daria J. Azizad, Xiang Li, Nardos Kebede, Alicia R. Lane, Priya E D'Souza, Parinya Panuwet, Emily J. Hill, Samantha N. Lanjewar, Anna J. Voss, Dorelle V. Fawwal, , Steven A. Sloan
This study shows that prenatal lead exposure biases neural cell fate in human brain development by increasing neurons and reducing astrocytes through epigenetic changes.
bioRxiv · Aug 14, 2025 · PreprintNeuroscience