Avoidance of MAIT cells is an essential determinant of Listeriamonocytogenes pathogenesis
Rafael Rivera‐Lugo, Jesse Garcia Castillo, Mariya Lobanovska, Eugene Tang, Andrea Anaya-Sanchez, Scott Espich, Sarah A. Stanley, Michel J.P. DuPage, Daniel A. Portnoy
This study shows that Listeria monocytogenes evades MAIT cells by lacking riboflavin biosynthesis, and engineered strains that produce riboflavin activate MAIT cells, offering therapeutic potential against infections and cancer.
Proceedings of the National Academy of Sciences · Jun 8, 2026Peer-reviewedMicrobiology